ChemicalBook > CAS DataBase List > SQ 22,536

SQ 22,536

Product Name
SQ 22,536
CAS No.
17318-31-9
Chemical Name
SQ 22,536
Synonyms
Ax 100;CS-2551;Nsc 53339;9-THF-Ade;SQ 22,536;SQ 22536;SQ-22536;SQ22,536/Inhibitor;SQ22536 (NSC-53339);9-(Tetrahydrofuran-2-yl);Tetrahydrofuryl-9-adenine
CBNumber
CB3289950
Molecular Formula
C9H11N5O
Formula Weight
205.22
MOL File
17318-31-9.mol
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SQ 22,536 Property

Melting point:
160-161℃
Boiling point:
474.8±55.0 °C(Predicted)
Density 
1.70±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: 21 mg/mL
form 
solid
pka
3.82±0.10(Predicted)
color 
white to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2934.99.9001
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S153
Product name
SQ 22,536
Purity
≥97% (HPLC), powder
Packaging
5mg
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
568500
Product name
SQ 22536
Purity
Cell-permeable adenylate cyclase inhibitor.
Packaging
5mg
Price
$187
Updated
2024/03/01
TCI Chemical
Product number
Q0105
Product name
SQ 22536
Packaging
10MG
Price
$156
Updated
2024/03/01
TCI Chemical
Product number
Q0105
Product name
SQ 22536
Packaging
50MG
Price
$560
Updated
2024/03/01
Alfa Aesar
Product number
J67455
Product name
SQ 22536
Purity
95%
Packaging
5mg
Price
$136
Updated
2023/06/20
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SQ 22,536 Chemical Properties,Usage,Production

Description

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.

Uses

SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.

Definition

ChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.

Biological Activity

Inhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets.

Biochem/physiol Actions

SQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.1 It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.2

storage

Store at +4°C

SQ 22,536 Preparation Products And Raw materials

Raw materials

Preparation Products

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SQ 22,536 Suppliers

China 84 Germany 1 India 2 Japan 2 Switzerland 2 United Kingdom 5 United States 23 USA 1 Global 120

17318-31-9, SQ 22,536Related Search:

Cyclic AMP 5'-IODO-5'-DEOXYADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 2'-Deoxyadenosine monohydrate 8-BROMOADENOSINE 3'-ADENYLIC ACID N6-ISOPENTENYLADENOSINE-D6 2',3'-O-Isopropylideneadenosine 5'-Tosyladenosine 2-Chloroadenosine 2'-Deoxyadenosine 5'-phosphate Vidarabine Adenosine 5'-monophosphate monohydrate Bucladesine sodium N6-BENZYLADENOSINE N6-Benzoyl-2'-deoxyadenosine 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE

  • 9-(2-tetrahydrofuryl)adenine
  • SQ 22,536 ADENYLATE CYCLASE INH
  • 9-(Tetrahydro-2-furynal)-9H-purin-6-amine
  • SQ22,536/Inhibitor
  • 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade
  • 6-Amino-9-[(tetrahydrofuran)-2-yl]-9H-purine
  • 9-(Tetrahydrofuran-2-yl)-9H-purine-6-amine
  • 6-Amino-9-(tetrahydro-2-furyl)-9H-purine
  • 9-(Tetrahydrofuryl)adenine
  • 9H-Purin-6-amine, 9-(tetrahydro-2-furanyl)- (9ci)
  • Adenine, 9-(tetrahydro-2-furanyl)- (8ci)
  • Adenine, 9-(tetrahydro-2-furyl)-
  • Ax 100
  • Nsc 53339
  • 9-(Tetrahydrofuran-2-yl)-9H-purin-6-aMine
  • 9H-Purin-6-aMine, 9-(tetrahydro-2-furanyl)-
  • 9-THF-Ade
  • 9-(Tetrahydrofuran-2-yl)
  • SQ 22,536
  • 9-(oxolan-2-yl)-9H-purin-6-amine
  • 9-(oxolan-2-yl)purin-6-amine
  • 9-(TETRAHYDRO-2-FURANYL)-9H-PURIN-6-AMINE
  • 9-(TETRAHYDRO-2-FURANYL)-9H-PURINE-6-AMINE
  • 9-(TETRAHYDRO-2'-FURYL)ADENINE
  • 9-THF-ADE;9-(TETRAHYDROFURAN-2-YL)-9H-PURIN-6-AMINE
  • SQ 22536 - CAS 17318-31-9 - Calbiochem
  • CS-2551
  • SQ 22536;SQ-22536
  • Tetrahydrofuryl-9-adenine
  • SQ22536 (NSC-53339)
  • 9-(Tetrahydro-furan-2-yl)-9H-purin-6-ylamine
  • 17318-31-9
  • C9H22N5O
  • C9H11N5O
  • G Proteins and Cyclic Nucleotides
  • Cyclic Nucleotide Metabolism
  • Adenylyl Cyclase Inhibitors
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience